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Furthermore, the inhibition of TGR by AF in cultured worms greatly reduced the GSH:GSSG ratio and resulted in rapid worm death

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These results may explain the ineffectiveness of the 10 μM dose of LA treatment, as the increased formation of peptide fragments (particularly LA fragment 2) may share enough similarities to the Zot and zonulin receptor-binding motif (G XXX VQ X G) to competitively inhibit LA binding to EGFR and/or PAR2